In the two years following the death of Elizabeth Keen, Raymond Reddington and the members of the FBI Task Force have disbanded – their lives now changed in unexpected ways and with Reddington’s whereabouts unknown. Finding themselves each at a crossroads, a common purpose compels them to renew their original mission: to take down dangerous, vicious and eccentric Blacklisters. In the process, they begin to uncover lethal adversaries, unimaginable conspiracies and surprising betrayals that will threaten alliances and spur vengeance for the past, led by the most devious criminal of them all – Raymond Reddington.
In the two years following the death of Elizabeth Keen, Raymond Reddington and the members of the FBI Task Force have disbanded with Reddington's whereabouts unknown. When one of their own is injured in the line of duty, however, the Task Force is drawn back together to bring down a conspiracy that could shatter global security.
The Task Force races to locate a blacklister who uses any means necessary to return what has been unjustly stolen. Ressler asks Park for a favor. Cooper tries to piece together an event for which he has no memory.
Dembe's position as an FBI agent causes complications for Red as the Task Force handles a case involving military technology. Cooper and Park each find their personal lives increasingly complicated.
The death of a professional tennis player leads the Task Force to a doctor who may be fixing the odds for a major sports betting syndicate. Red digs deeper into Dembe's betrayal. Ressler struggles with sobriety.
A spate of coordinated attacks on Red's lieutenants puts Dembe in imminent danger, prompting him to relive the events that led him to join the FBI two years earlier.
The task force's investigation into Arcane Wireless, an untraceable cellular network for criminals, leads to unexpected consequences. Red races against the clock to get a colleague out of trouble.
An investigation into the Conglomerate, a group of former government-sponsored assassins, becomes complicated when the Task Force learns one of their own may have ties to the group. Red digs deeper into the events leading up to Liz's death.
The Task Force pursues their latest target, the Chairman, who operates a dark web stock market trading shares of criminal organizations. Red takes extreme measures to locate a tracking device, which sends Ressler into a spiral. Cooper makes contact with his blackmailer.
The Task Force is led to an unusual suspect when the wealthy clients of an apparent escort service start turning up dead. Red and a friend attempt to recover an item after reuniting at a friend's memorial. Cooper heads to Atlanta to follow a lead on his blackmailer.
While searching for Sen. Panabaker's missing daughter-in-law, the Task Force learns there may be a larger pattern of abductions. Red continues piecing together the mystery behind Liz's death.
Red chases a lead that could shed light on both Liz’s death and Cooper’s blackmailing. The Task Force experiences a major shakeup when one of their own is taken into custody.