"Karma" should be a four-letter word. Just ask Earl, the lovable loser with a hilarious laundry list of dirty deeds that need undoing, from stealing a children's bookmobile to getting his babysitter pregnant - the hard way! And, while Earl's brother Randy starts a karmic list of his own, Earl's ex-wife, Joy, and her husband are movin' on up to the suburbs. Trouble is, you can take the girl out of the trailer park, but you can't take the trailer park out of the girl.
When Joy cons Make-A-Wish to send a celebrity to her trailer, Earl remembers a wish he stole from a dying child and decides it's time to cross him off the list. When he returns to the kid's home, he finds that little Buddy has exceeded all of the doctors' expectations and is still alive. Buddy asks Earl to produce his movie and suddenly all of Camden County find themselves starring in a high-octane action film. Randy surprises everyone when his acting skills get rave reviews.
Earl and Randy decide it's time to make amends with their childhood neighbors, the Clarks. But when they discover more skeletons in the closet than they had expected, the brothers find themselves needing to sort out some family issues between their mom and dad. Meanwhile, Joy has duped one-eyed Willy out of his glass eye, and despite Darnell's efforts Willy may never "see" that eye again.
Earl's attempt to give Joy the hot tub she's always wanted backfires and she is forced to stay in a makeshift bubble because of a flesh eating toe infection. While she is out of commission, Earl must fill in as the new Joy. Between gossiping with the ladies at the salon and shopping for meat out of some guy's trunk, Earl learns about the Turner family. This includes the fact that Dodge and Earl Jr. might have a social disorder that causes them to have no friends. Can Earl fix this problem too?
To cross Jerry off of his list, Earl can't just return the RV he stole, mostly because Randy blew it up. Earl and Randy set out to find what might make this grumpy war hero happy, and accidentally turn him into a 75-year-old killing machine. Elsewhere, Joy and Darnell attempt to turn the legend of a giant pig that lives near the trailer park into a one-of-a-kind, money making sideshow.
To cross Randy off his list, Earl takes his brother to cheerleading camp. Once there, the tight cheer pants and their lack of flexibility are not their only problem. They also have to deal with Kimmi Himmler, the camp owner with a deeply scarred face and milky eye - both a result of a badger accident suffered while cheering in high school. When Himmler wants the brothers out of her camp, Earl goes to drastic measure to make sure that Randy's cheerleading dreams will come true. Elsewhere, Joy is hurt when her son Dodge indicates that Catalina is the most beautiful woman in Camden.
When Randy's birthday is coming up, Earl gets him a new car, but it is stolen before he can present it to Randy. Apparently, Earl no longer falls under the code of criminals, that no criminal steals from another one. Now that he is treated as a "civilian", he needs to decide whether to take the matter to the police and become a snitch.
Earl plans a Halloween party for Dodge and Earl Jr, while Catalina's nephew Oscar visits. This poses an opportunity for Randy to become the big brother he always wanted to be.
Suddenly at the top of Earl's list a life-or-death item appears right after a new mysterious man moves in next door. Meanwhile, a science fair has Joy all worked up to the point of obsession. She' so fixated on winning the fair so she can buy something special with the prize money.
Earl remembers his first wedding anniversary and the events that finally lead to their break up, involving Earl's cousin Blake and an invasion of killer bees.
Earl loses his list while tornado's hit Camden County. Meanwhile, Randy thinks he's invincible after a wild boat ride and contemplates how he should use his new found power. Elsewhere, who's the smartest, Joy or Darnell? that's what this weeks argument is about and Catalina and Patty have a religious awakening.
Earl remembers a list item he crossed off while reading to the children of Camden County. While going down memory lane, Earl recalls that his old friend Raynard kept company with a raccoon while living in the great outdoors.
A young Earl gets his heart broken by the babysitter and swears revenge on her and her boyfriend. Now, Earl is older and wiser, so he decides to cross them off his list, but it may have terrible repercussions for Randy. Meanwhile, Joy loses Darnell's pet turtle
In the aftermath of having his cover blown, Darnell must pack up and leave Camden. Meanwhile, Earl, Randy and Catalina discover a devastating truth within the post office.
When Randy loses his winning lottery ticket, he assumes the event to be a message from Karma, so he starts a list of his own. Meanwhile, Joy is not happy with her cover identity of the witness protection program.
When Mr. Turtle returns back to Earl, he wants to bring him back to Darnell. Meanwhile, Joy and Darnell have to adapt to a new lifestyle of their cover identities.
Danny Glover guest stars as Darnell's father who comes looking for him in Camden only to raise Earl and Randy's suspicions. However, a family reunion leads to father and son partaking in one last undercover mission.
Randy busts into the motel room, demanding that Earl drive to Joy's and punch her in the face. Over time, Randy has invested lots of time and money in the Crab Shack's claw machine, but every time he wins a cute stuffed animal, Joy bullies him into giving it to her. This last time he won a fancy bird dressed up for a wedding and the loss has put Randy over the edge. Earl points out that Randy is 32 years old, and it's time he learned to stick up for himself - Earl's not going to protect him anymore.
News show "Inside Probe" investigates the disappearance of the Crab Shack owner. After eight years the show airs on TV, and several Camden residents become murder suspects.
When Dodge tells Joy he doesn't want Darnell to speak at career day, she enlists Earl to pretend to be his father. Things don't go well and Earl realizes Dodge needs to know his real dad. Despite Joy's protests, Earl enlists Randy and Catalina to help him hunt down the deadbeat dad, but what they discover is worse than they could have imagined.