In Nice, Frank is hired by Dieter's friend Trina to deliver an engine prototype to the Paris Motor Show. They race towards Paris but are pursued by an assassin nicknamed The Wolf. Unfortunately the prototype emits a trackable GPS signal.
Frank's latest job goes completely wrong: he loses his package in a holdup and is accused by his Russian gangster employer of having embezzled the money.
The Transporter's package is a beautiful young woman who's caught in the crossfire between her disgraced General father, and the criminal syndicate hunting him.
Frank faces a dilemma when he finds out his package is a heart meant for transplantation stolen by his crime lord client to save his own son and when Inspector Tarconi informs him that another dying boy is waiting for it at the hospital.
In Philadelphia, Frank meets Jack Perkins, his CIA instructor. The blind man is being framed for leaking secret documents. Frank must find a USB key containing evidence that can clear Jack's name and reveal the real mole's identity.
As he's waiting for his package to be delivered in a Toronto parking lot, Frank finds himself faced with a series of strange coincidences. He understands he fell into a trap when the police throws him in jail, accusing him of a crime he didn't commit. His imprisonment is supposed to allow to get a very protected package out of the prison walls: the hand of a mob boss who's just been murdered...
Frank must transport a million euros from Paris to Marseille while racing against two other elite runners each with the same package and destination. The client whose transporter wins will gain an important missile contract. Word of the race has reached two gangs that decide to try and rob the money but Frank, who needs to prove he's the one and only worthwhile transporter on the market, doesn't intend to let himself be swindled... The task is further complicated by a mysterious hitchhiker, who can not be shaken off and wants to know everything about Frank. Frank manages to end up as the lone transporter to finish the race, but victory is bittersweet, due to the loss of an old friend, who was one of the other two transporters in contention.
Frank is hired to bring a package from the south of France to Paris. Once there, he realizes the package is a bomb meant for a planned terrorist attack.
Frank is to pick up a valuable painting from a gallery and bring it to a rich art collector. There is a wild chase during the transfer and a young woman threatens him with a gun and claims that the painting is hers. Fortunately, at this moment the police appears and Frank seizes the opportunity to wriggle out of the situation. But when he delivers the painting to art collector Max Khyber (Hannes Jaenicke), it turns out that it is a fake. Khyber feels betrayed and suspects Frank. He holds Frank prisoner on his property and sends in a dominatrix to get him to to talk, but Frank manages to free himself and goes in search of the original.
Frank has twelve hours to transport a stolen microchip, meant for the development of advanced weaponry, before the rigged package kills him. In a race against time, Frank must find a way to force the client to neutralize the deadly device.
Frank has to transport a young hacker to her new employer. But the employer is not the only one that is interested in the girl. Meanwhile, Frank has a lunch date with Juliette that doesn't exactly turn out to become a romantic moment.