Agent Luke Alvez (Adam Rodriguez) joins the BAU team, which is tasked with capturing a killer who escaped prison with 13 other convicts at the end of last season.
When three children disappear while riding their bikes on the same path as a similar unsolved disappearance 30 years ago, the BAU team comes in to investigate.
The BAU team opens an investigation when a man who fully believes he’s Dr. Tara Lewis’ brother arrives in town, knowing everything about her and her family, and she is unable to make contact with her real sibling.
While Rossi conducts a profiling course on his birthday, he receives a call from his nemesis Tommy Yates, who discloses the location of his latest victim.
Reid has returned from Houston, where he was visiting his mother who is in a new facility on an experimental drug program. He is called back home from the office while the rest of the team heads off on their next case. It isn't until the team is in the air that they learn that Diana is no longer in the Houston facility, but that she is now living with Reid, as the trial drug was not having the intended effect.
The BAU investigates when several young men and women are victims of disfiguring acid attacks. Also, Dr. Reid begins to settle into his new surroundings.
When three women in New York City are found dead with several bones broken, the BAU works with a single mother (Tatum O'Neal) who believes that her son is behind the heinous crimes. Meanwhile, Reid faces a difficult decision after a fellow inmate is threatened.
When two drastically different murder sprees are committed in Burlington, Vermont, the BAU concludes that a serial killer suffering from sleepwalking is responsible for both crimes. Meanwhile, Alvez presents Shaw with a shocking ultimatum after Reid is assaulted in prison.
The BAU investigates an urban vampire who kidnaps his victims at night and holds them underground in the sewer system; Reid makes a difficult decision in prison.
The BAU investigates when several federal government employees, including a close friend of Walker's, succumb to symptoms of a heart attack; Reid anxiously awaits his trial date.